this post was submitted on 14 Jan 2025
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Summary

Bryan Johnson, a 46-year-old tech multimillionaire focused on anti-aging, stopped using rapamycin—a supplement he took for five years—after research suggested it might accelerate aging.

Johnson cited side effects like skin infections and glucose issues, as well as findings from a recent study showing rapamycin could worsen epigenetic aging.

Known for extreme anti-aging experiments, Johnson also created the health startup Blueprint, which markets pricey supplements.

His controversial methods, including teenage blood transfusions and genital shock treatments, have raised skepticism about their effectiveness and safety.

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[–] [email protected] 6 points 6 hours ago* (last edited 6 hours ago)

Is this the trickle down economics everyone is talking about? shall we again start selling uranium, platinum etc beverages to the rich?

He has a team for this?

“Despite the immense potential from pre-clinical trials, my team and I came to the conclusion..."

Forget trickle down economics, this is insane just bring the guillotines.

[–] [email protected] 8 points 8 hours ago

I see the proud tradition of drinking mercury concoctions is alive and well. I mean, not well, but...

[–] [email protected] 16 points 10 hours ago

This guy looks like he's 60 cosplaying as a 20 year old

[–] [email protected] 2 points 7 hours ago

This is one of the biggest wastes of time I could imagine.

[–] [email protected] 7 points 11 hours ago (1 children)

It would be hilarious if the societal collapse caused by wealth inequality resulted in him getting murdered. I would laugh and laugh.

[–] [email protected] 0 points 8 hours ago (1 children)

To think that a societal collapse would stop a billionaire from hiring armed guards is absurd. By the time that guy is murdered, you'll be so long dead.

[–] [email protected] 1 points 7 hours ago

Who cares at that point?

[–] [email protected] 17 points 13 hours ago (2 children)

This dude is just going to spend a bunch of money on shit that will eventually kill him. What a waste.

[–] [email protected] 4 points 7 hours ago

What an efficient allocation of capital!

[–] [email protected] 4 points 12 hours ago (2 children)

That's what we all do every day, this guy just has more to spend

[–] [email protected] 2 points 7 hours ago* (last edited 7 hours ago)

Nah some of the shit we buy sustains us, and some of the killer shit we buy at least provides joy. This guy is just a miserable, wasteful asshole.

[–] [email protected] 1 points 7 hours ago

You have to see this guy's routine. His life is built around attempting to extend his longevity. He lives like a luxurious lab rat being pocked, prodded, measured and eats/drinks/sleeps/exercises on a ultra-strick program.

It seems miserable.

[–] [email protected] 27 points 15 hours ago (2 children)

"genital shock treatments"

Ok..... how did someone sell that as an anti-aging treatment?

[–] [email protected] 7 points 7 hours ago

I don't usually like salespeople, but this one I like a lot.

[–] [email protected] 18 points 14 hours ago (1 children)

The salesman: "anti-what?"

[–] [email protected] 7 points 10 hours ago

The passing of time must be stored in the balls.

[–] [email protected] 36 points 18 hours ago (2 children)

Watched the documentary with a friend; we were trying to guess his age. We agreed on "decent looking for 55". He's 47 lol.

[–] [email protected] 20 points 17 hours ago* (last edited 17 hours ago)

People who are obsessed with some physical quality about themselves always make whatever the issue is, like 1000% worse than if they just left it alone and lived normally.

[–] [email protected] 12 points 17 hours ago (1 children)

His face looks old enough to make his hair look unnatural.

[–] [email protected] 5 points 12 hours ago

It looks like a wig.

[–] [email protected] 57 points 20 hours ago (1 children)
[–] [email protected] 3 points 8 hours ago

I just watched this movie again today, wasn’t expecting a meme of it so quickly!

[–] [email protected] 199 points 1 day ago (6 children)

It's an unpopular opinion, but I actually appreciate this guy and what he is doing. He has opted to open his entire research and data to anyone that wants to look at it. So, even though he is definitely a weirdo, the data he is providing might be of some use.

I don't want to look like a vampire, but if his research leads to the discovery of some protein that allows my heart to beat at full strength for a little longer, or slows down the onset of dementia, etc., then I'm all for him wasting his money trying to look like a Twilight cast member.

[–] [email protected] 4 points 7 hours ago* (last edited 7 hours ago)

It's one guy who is going through like a million treatments.

It's cool that the data is available but what helpful information can be gained from it other than "what happens if you do jackass but healthy?"

[–] [email protected] 122 points 23 hours ago (1 children)

I like that he's willing to really fuck up his own body to see what happens. I don’t like that he's peddling supplements.

[–] [email protected] 51 points 23 hours ago

Notice I used the word "appreciate" instead of "like".

[–] [email protected] 52 points 22 hours ago (3 children)

This isn't real research ... it's just a millionaire spending money on trying to live longer for themselves while selling and marketing products on the side.

If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.

Watching one guy testing and trying out a few things whenever he feels like it and done at his own whim and under only his opinion and likes and dislikes is not research.

The biggest contribution he has to longevity is in promoting and advertising the fact that one of the ways to extend your lifespan is to become a millionaire.

[–] [email protected] 19 points 15 hours ago

Someone testing on themselves is how we learned what causes and how to treat ulcers (the researcher earned a Nobel prize for giving himself an ulcer, and then treating it), among other things.

Controlled trials are great, but research has to start somewhere.

[–] [email protected] 16 points 16 hours ago (1 children)

You're telling me that shocking one's nards on a hunch and writing it down isn't real research?

I'm starting to think I know nothing about science. What have I been doing?

[–] [email protected] 5 points 16 hours ago

I'd love to see your research on shocking your nards ... especially to be able to see the video evidence of what happens and what the results are.

[–] ArbitraryValue 5 points 16 hours ago* (last edited 16 hours ago)

If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.

For most of the time since the start of the Scientific Revolution, the way this guy does research was the standard way that research was done. Controlled clinical trials certainly have an important role in the development of new medicines, but they're slow and expensive. They aren't good tools for quickly trying out a lot of very speculative ideas. I expect that if a powerful anti-aging technique is discovered, it will be used for self-experimentation years before a clinical trial.

A couple of caveats: first, I think that a powerful anti-aging technique is probably not possible with today's technology or the technology of the near future. Second, I think the self-experimentation is more likely to be done by a scientist in an academic lab studying senescence than by someone doing research outside of academia.

[–] [email protected] 58 points 23 hours ago (2 children)

But he's involving so many variables, is his data even useful? I don't understand how you could extrapolate anything from a guy who takes so many supplements that may cause conflicting outcomes.

[–] [email protected] 42 points 23 hours ago (3 children)

Someone who has a background in science would know that testing on a single person is not very useful for what other posters are wishing for (new proteins, new anti aging treatments).

This billionaire has age dysmorphia and is using his wealth to experiment around. It’s unfortunate really.

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[–] [email protected] 3 points 11 hours ago

It would be hilarious if the accelerated aging from the supplement undid all the progress he made from all the other stuff lol.

[–] [email protected] 17 points 17 hours ago

Had to check this wasn’t nottheonion

[–] [email protected] 20 points 18 hours ago

I bet I live longer than him, and on a shoestring budget

[–] [email protected] 3 points 13 hours ago (1 children)

You can't cheat life. We must all age..

[–] [email protected] 3 points 8 hours ago

He seems to actually believe there is a way to live forever. And he's spending millions per year to get there. He said he wants to show the world how to stop ageing. When asked how everybody should be able to spend as much resources as he does, he said society has to figure that out. Besides the fact that cost-intense trestments will only benefit the wealthy there wasn't one word about overall resource management, when people will die much later, but babies are born continuously. And the sentence about society has to figure it out really made me angry. Society already figured out billionairs are an issue and often enough the cause for many poor people suffering. But this doesn't change anything, cause the rich make the rules.

[–] [email protected] 17 points 19 hours ago

The guy looks like one of those Kraftwerk robots.

[–] [email protected] 24 points 21 hours ago (1 children)

I watched his video describing a day in his life, sleep at 8pm and wake up at 5am, then take 50 pills, his whole day revolved around preparing for sleep, which he said was the most important thing, so I guess he's right about that. But just thinking a tiny change in his life, even travelling, will upset this routine, then what, the stress from that routine is probably aging him the most.

[–] [email protected] 16 points 20 hours ago* (last edited 20 hours ago) (1 children)

That’s the thing, he might live a bit longer but at what cost? I would much rather enjoy my life than by a slave to a miserable routine dedicated to promoting longevity that will potentially buy me an extra decade. Like I can just eat a somewhat reasonable diet, exercise, sleep okay and with decent genetics based on my parents and grandparents I will probably make it to at least mid to late 80s, maybe longer if medicine advances. If I had genetics that suggested a strong likelihood that I would die in my 60s I would maybe be more interested

With this guys routine I could maybe push that to 100ish? I would certainly love to extend my life but not at the cost of it consuming my life. I assume he’s banking on getting to the theoretical max though, which is probably closer to 120ish, and that is substantial but then it’s like a few decades of extremely decreased mobility and mental acuity? Eh

And of course this all disregards the potential that you get cancer, murdered, car accident, etc.

[–] [email protected] 8 points 18 hours ago

I truly believe he loves doing this so no cost to him as far as mental health/stress goes. Sounds like you are doing most things right so that pretty much covers the 80/20 rule. Johnson is trying to live indefinitely without losing mobility or mental faculties. It's great that we have someone testing things out and adjusting when things don't work.

[–] [email protected] 27 points 22 hours ago (1 children)

this guy sucks. He's conducting essentially a thousand uncontrolled trials on himself making them all useless unless he dies of a new contraindiction

[–] [email protected] 16 points 21 hours ago (4 children)

Why does he suck though? Aren't we all conducting uncontrolled trials on ourselves? Better that, than doing it on other people, right?

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[–] [email protected] 41 points 1 day ago

Hah, sounds like his "research" is trying it out on himself and deciding he didn't like it. And now that he doesn't like it, all of a sudden he finds the research valid. He's still only listening to opinions he agrees with. What a shallow twat.

[–] [email protected] 33 points 1 day ago (3 children)

Rapamycin

It's not just "one of many" it was the big one that has a large online following swearing by it, and lots of idiots taking it.

Also I can't see a pic of this guy without thinking of Dennis Reynolds asking if he should wear a mask of his own face.

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