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Big Lebowski. Jeff Bridges.

A live-action Lorax. Danny DeVito is the only human, and he's wearing a Lorax costume.

OG Star Wars - chewbacca, but instead of a guy in a costume just a really hairy dude

Weekend at Bernie's. Bernie.

Interstellar - Anne Hathaway

Inglorious Bastards, we keep Christoph Waltz

Bonus points if the actor is not the protagonist

Buried with Ryan Reynolds. Just Kermit on the phone.

Clue, Tim Curry

My wife said: Legally blond, keep Witherspoon

The Muppet Christmas Carol

Michael Caine

Am I doing this right?

The Prestige. Christian Bale.

But he only plays "half" of Borden.

This was done with a Muppet Christmas Carol and Michael Caine to excellent results. Really a top notch interpretation and acting. Highly recommend

Jaws - Jaws

Blade 3. Ryan Reynolds.

National treasure, Nick Cage.

Rocky, the lady who played Adrian.

Jurrasic park, the guy that played Neuman on Seinfeld.

Shawshank redemption, Morgan Freeman.

Being John Malkovich,

Keep anyone other than John Malkovich, in fact John Malkovich is the only puppet.

Cast Away. Tom Hanks.

It's a movie that starts really goofy, gets serious for a long time, and is then oddly goofy again.

All of Star Wars - JarJar's actor

Transformers. Keep only John Turturro. The rest, even the Transformers, are played by normal sized muppets.

Bumblebee is played by Beaker, obviously. And seeing Megan Fox replaced by Miss Piggy sounds like a fever dream

The Secretary - Maggie Gyllenhaal

Kiss Kiss Bang Bang - RDJ (I think this one would be fun the muppets could pull this off well)

Saving Private Ryan - Tom Hanks

Precious - Gabourey Sidibe

I am Legend - the dog

Being John Malkovich - John Malkovich
~~also Airplane! - John Malkovich~~

the man was made to pitch a fit in front of a bunch of muppets

edit: i looked it up and apparently he wasn't in Airplane! ...? am i going crazy?

edit 2: I was confusing Stephen Stucker playing the crazy guy Johnny with John Malkovich

Airplane - Stephen Stucker

Star Trek II: The Wrath of Khan. Keep Ricardo Montalban.

Edit: Alien. Keep Sigourney Weaver.

Home Alone - keep Kevin

The Matrix. Hugo Weaving (Agent Smith) as the only non-muppet.

The Princess Bride. Keep Fred Savage, but as an adult.

Sonic the Hedgehog, Jim Carrey

Memento, with any of Guy Pearce, Joe Pantoliano or Carrie-Anne Moss. All would be good

The Matrix, with either Lawrence Fishburn or Joe Pantoliano (again lol)

The Holy Mountain

Keep Jodorowsky.

Fifth Element - Bruce Willis

The attempted mugging would be hilarious. The cookie monster screaming "gimme da cookies!" Miss Piggy as the supreme being.