sh.itjust.works

The Fed has made significant progress tackling inflation through interest rate hikes in the last two years, and recently began paring rates back in a bid to boost demand in the economy and support the labor market. In the last couple of months, the Fed's favored inflation has ticked higher, moving away from the bank's long-term target of two percent, and raising concern that the battle against inflation is not over.

Nevertheless, the financial markets still overwhelmingly expect the Fed to announce a quarter percentage-point cut on Wednesday, lowering its benchmark lending rate to between 4.25 and 4.50 percent, according to CME Group data.

"If the Fed wasn't going to do that, they would have dissuaded markets of that notion a long time ago," Moody's Analytics chief economist Mark Zandi told AFP on Tuesday.

A cut on Wednesday would be the Fed's third in a row and would leave rates a full percentage point below where they were just three months ago. "I'm dubious that another cut is necessary," Citigroup global chief economist Nathan Sheets told AFP. But a rate cut on Wednesday is "very much baked in" at this point, he said.

This is the final planned interest rate decision before Democratic President Joe Biden makes way for Republican Donald Trump, whose economic proposals include tariff hikes, and the mass deportation of millions of undocumented workers. These proposals, combined with the recent uptick in inflation data, have led some analysts to pare back the number of rate cuts they expect in 2025, predicting that interest rates will need to remain higher for longer.

cross-posted from: https://lemmy.world/post/23272168

A growing number of local governments are beefing up safeguards.

cross-posted from: https://lemmy.blahaj.zone/post/19707444

cross-posted from: https://lemmy.world/post/23233801

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Abstract

Background: Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel is the only fixed-dose triple-combination approved for acne (indicated in patients 12 years and older). As topical acne treatment in pediatric patients may be complicated by tolerability and/or a perceived lack of efficacy, post hoc analyses were used to investigate efficacy/safety of CAB in children and adolescents.

Methods: Data were pooled from 2 phase 3, double-blind, 12-week studies (NCT04214639; NCT04214652). Participants aged 9 years and older with moderate-to-severe acne were randomized (2:1) to once-daily CAB or vehicle gel. Endpoints included treatment success (at least 2-grade reduction from baseline in Evaluator's Global Severity Score and clear/almost clear skin) and least-squares mean percent change from baseline in inflammatory/noninflammatory lesions. Treatment-emergent adverse events (TEAEs) and cutaneous safety/tolerability were evaluated. Post hoc analyses were conducted in adolescents aged 12 to 17 years (CAB, n=123; vehicle, n=50) with descriptive data shown for children aged 10 to 11 (CAB, n=3; vehicle, n=2).

Results: At week 12, 51.5% of CAB-treated adolescents achieved treatment success vs 24.9% with vehicle (P<0.01). CAB also provided inflammatory/noninflammatory lesion reductions of 78.3%/73.7% vs 50.5%/42.9% with vehicle (P<0.001, both). Most TEAEs were of mild-to-moderate severity, and <2.5% of participants discontinued due to adverse events. Only the 3 children treated with CAB achieved treatment success, with lesion reductions ranging from 76% to 100%. One CAB-treated child experienced TEAEs and none discontinued.

Conclusions: In 2 pooled phase 3 studies, once-daily CAB gel was well tolerated and efficacious in pediatric participants with acne, with over half achieving treatment success at week 12. J Drugs Dermatol. 2024;23(12):1049-1057. doi:10.36849/JDD.8643.

From the Atlanta Daily World:

Atlanta Falcons head coach Raheem Morris made the decision to bench veteran quarterback Kirk Cousins in favor of rookie Michael Penix, Jr.  After a hot start to the season where he led a game-winning drive against the Philadelphia Eagles and threw for over 500 yards against the Bucs, Cousins experienced a severe slump.  Before entering … Continued

The post Michael Penix, Jr. To Replace Kirk Cousins As Falcons Starting Quarterback: Here’s What To Expect appeared first on Atlanta Daily World.

Mehr Infos zum Heft: https://www.kultboy.com/magazin/4502/

De nieuwe Pixar-serie Win or Lose zou eigenlijk een transgender personage krijgen, maar moederbedrijf Disney heeft daar nu toch van afgezien. Dat meldt Variety woensdag.

Wall Street financiers were a clear target of the tax, but some, on questionable legal grounds, have claimed their outsized profits were exempt, sometimes avoiding hundreds of millions in taxes.