Checked it with multiple reverse image search engines, and I can't find it anywhere before 2021. It was posted that time related to the other drive-by meme, I guess someone saw the new meme, and remembered Malcolm had a very similar scene 15 year earlier, searched the episode and made the screenshot.
2005 was before these kind of labeled reaction memes even existed. Know Your Meme has 3 Malcolm memes documented, all of them started to spread more than a decade after they aired:
- The Future Is Now, Old Man 2002 vs 2016
- Once You Start There's No Going Back 2000 vs 2021
- Wow, I Can't Find a Flaw In His Logic 2000 vs 2013
So even if this scene was used as a gif before 2021, its usage as a meme should came after the Umbrella Academy version was known
The one you linked is 10 hours, but here is a 1 hour long version: https://www.youtube.com/watch?v=YmHZI03a_Yo
But this was uploaded after the post in question, so it's still not the same one. As side note it's unbelievable how many videos of this "genre" are on yt .