The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
100%
I don't like how r/conservative handles their moderation but I don't think their subreddit should be nuked.
But things like Men Going Their Own Way, and The Donald or any other subreddits promoting violence and direct hate deserve removal (or de-federation). De-federation should be used as a tool of last resort. For places who are turning to actual violence or outright hatred.
I cannot stress how strongly I disagree with exploding-head's stance on Trans rights and racism but if someone has an odious opinion on gender affirming care or trans athletes then they should be met by people who counter their ideas. Simply cutting them off into isolation provides zero chance of changing their minds.
I understand that some people have no interest in debating people who disagree with them, and that is entirely ok. Block any community or poster that you find offensive but defederation is not something that should be used regularly.