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Single psilocybin trip delivers two years of depression relief for cancer patients
(www.sciencedaily.com)
this post was submitted on 21 Jun 2025
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Dude start off with something more mellow, or you're going to be extremely disappointed if/when you decide to try other drugs. Psychedelics are so intense that I don't even consider them to be drugs. They're something else entirely. A "god molecule", if you will.
I'd suggest starting off with Nitrous Oxide and/or weed first. Nitrous has psychedelic properties (but without the visuals), and cannabis can also be psychedelic when you have no tolerance. Also they last more in the minute range—not hours (especially nitrous)—so they'll wear off a lot quicker should you decide you don't like the feeling.
Trust me, I've tried every drug under the sun. I'm a daily or near-daily user of several substances; psychedelics like shrooms are the one substance that I avoid. Only for special occasions, once every few years at most. Not the very first thing I'd try. It would be the very last.
Everybody is different, and it depends on what you're after. Research different substances of interest, how they work, contraindications, best practices for use, and the kind of effects they have. From there, select any specific substance you want to try, and do so responsibly.
There's lots of folks out there who have done mushrooms or other psychedelics as their first non-alcohol psychoactive experience. The trick is getting at least some understanding of what you're getting into first and preparing accordingly. I also wouldn't compare different compounds with different effects/mechanisms of action in a way that would make you disappointed/underwhelmed/whatever. They're different and should be evaluated on their own terms.
That's just me though.
I appreciate the deep personal insights and advice. Well taken.
Okay great. Now this stranger on the Internet would recommend not listening to that stranger on the Internet.
Do not take nitros oxide. Not only is it dumb as fuck, it literally gives you nerve damage, among many other side effects that anyone could find with a short simple search.
Weed and mushrooms are two of the best drugs on the planet and have minimal long term negative effects. I love mushrooms and it's all about dosage- how many grams and how strong is it per gram. NO it will not ruin your perception of other drugs. Acid is way stronger I'd recommend avoiding unless you have a whole week to recover.
Just vape weed or better yet take edibles and some mushrooms you should have near 0 negative physiological effects. Why tf would you do laughing gas you'll damage yourself what is this a street party in 2005 god damn. Not to mention just makes you act like a damn fool
I'd like to offer the counterpoint that someone once advised me not to try weed until after I'd tried LSD, I followed that advice and I think it turned out for the better. There isn't exactly a benefit to being very impressed by the intensity of other drug experiences, and psychedelics can give you a sense of perspective about what you want out of life that's useful for navigating choices. They also tend to be self-deterring; you likely will feel more satisfied and grateful to have your feet on solid ground again after a trip, as opposed to immediately craving more, even if it was wonderful, which is a very convenient property many other drugs lack.
I've only done it a few times, but nitrous made me laugh so much, it was great. Nitrous starts fading as soon as you breathe out and is over in 10min tops, but for weed, give yourself an evening to get stoned for the first time. Feeling cramped for time is a huge vibe killer.
Also, modern weed can be way too strong for a first-timer, but if you can find a low-thc/high-cbd strain, you'll have smooth sailing. My poor in-laws hadn't smoked since the 60s, and the budtender sold them a thc vape, good times were not had. Don't make their mistake, haha.