If you're replacing all of O365 (excellent choice, BTW), I do recommend Nextcloud with a few plugins. I use it specifically for sharing contacts and calendars among my family.
LibreOffice is my desktop word processor and spreadsheet, and I use it more than OnlyOffice, but if you need two people in the same file at the same time, OnlyOffice is a better option.
From the top of my head, compared to ext4: RAM use and the ability to shrink an FS if necessary. Oh, also I've used an EXT FS driver on a Windows host, but I've never seen one for XFS.