this post was submitted on 21 Jan 2025
133 points (98.5% liked)

Science

3371 readers
415 users here now

General discussions about "science" itself

Be sure to also check out these other Fediverse science communities:

https://lemmy.ml/c/science

https://beehaw.org/c/science

founded 2 years ago
MODERATORS
 

Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

top 21 comments
sorted by: hot top controversial new old
[–] [email protected] 3 points 24 minutes ago

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[–] TacoButtPlug 1 points 46 minutes ago (1 children)

I wonder what melatonin does

[–] [email protected] 1 points 43 minutes ago (1 children)

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[–] TacoButtPlug 2 points 21 minutes ago

Charlie Kelly... who taught you about Lemmy?

[–] [email protected] 1 points 1 hour ago* (last edited 1 hour ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[–] [email protected] 3 points 2 hours ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[–] [email protected] 7 points 4 hours ago (1 children)
[–] [email protected] 2 points 42 minutes ago (1 children)
[–] [email protected] 1 points 29 minutes ago

Then gets you really sleepy

[–] Gullible 40 points 9 hours ago

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[–] [email protected] 27 points 8 hours ago (1 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] [email protected] 3 points 8 hours ago (2 children)
[–] [email protected] 16 points 7 hours ago

The hat man cleans your brain for you.

[–] [email protected] 4 points 6 hours ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[–] [email protected] 12 points 9 hours ago (1 children)

I wonder if ketamine has the same effect, he asked apropos of nothing...

[–] [email protected] 9 points 9 hours ago (1 children)
[–] [email protected] 8 points 8 hours ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[–] [email protected] 5 points 8 hours ago (1 children)
[–] RvTV95XBeo 4 points 3 hours ago

That usually helps me sleep better too

[–] [email protected] 2 points 8 hours ago (1 children)

Apparently the water supply in my town is dosed with sleeping pills.

[–] pelespirit 7 points 8 hours ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater