this post was submitted on 19 Jul 2023
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A team led by famed Harvard Medical School anti-aging researcher David Sinclair has just published a paper that shows a mix of chemicals are capable of reversing cellular aging...

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[–] [email protected] 23 points 2 years ago* (last edited 2 years ago) (4 children)

I look forward to having a class of rich people who will never die with the rest of us being considered expendable /s

[–] [email protected] 6 points 2 years ago (1 children)

Literally a sub plot of the red mars series.

[–] teft 6 points 2 years ago

Also a plot on Altered Carbon. “Meths”, short for methuselahs, rule the world. You get a new body if you can afford it otherwise you get what we give you.

[–] [email protected] 5 points 2 years ago

Remember not aging doesn't necessarily mean immortal.

https://www.wikihow.com/Build-a-Gallows

[–] [email protected] 4 points 2 years ago (1 children)

Great, they'll live to see the consequences of climate change and slowly die anyway

[–] [email protected] 5 points 2 years ago (1 children)

They will move to subterranean refuges and keep their everlasting bodies connected to the metaverse.

[–] [email protected] 2 points 2 years ago* (last edited 2 years ago) (1 children)

So... this is what hell was referring to all along?

  • evil people: check
  • underground: check
  • everlasting: check
  • ~~metaverse~~ torment: check
[–] [email protected] 1 points 2 years ago

I mean, if I had to spend some hundred years in that fun-less wii loby controlled by the Zuck...

Which is a great plot for Black Mirror. Netflix, call me.

[–] [email protected] 1 points 2 years ago

Oh yes, I really look forward to a future where people like Trump or Rupert Murdock live forever.

[–] [email protected] 5 points 2 years ago

It’s Sinclair, stuff around him always gets overly-sensationalized, but skimming though the actual paper… damn, it looks surprisingly promising.

[–] [email protected] 5 points 2 years ago

Abstract

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript profiles, and tissue function, without erasing cellular identity, a process that requires active DNA demethylation. To screen for molecules that reverse cellular aging and rejuvenate human cells without altering the genome, we developed high-throughput cell-based assays that distinguish young from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic compartmentalization (NCC) assay. We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.

https://www.aging-us.com/article/204896/text

[–] [email protected] 2 points 2 years ago (1 children)

and surely everyone will benefit from this right? not just the rich? right?

[–] [email protected] 1 points 2 years ago

Depends on if you believe history, which shows technology always spreads, or Hollywood, which would have you believe in conspiracy theories.

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