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This reminds me of the research on saccharine that involved massive doses of it in mice. The belief that pumping huge amounts into a mouse can substitute for lower levels over long times always struck me as odd. Most systems, especially biological ones, have a critical level where systems fail. An example is the body's ability to process toxins like alcohol in the liver. If you overwhelm the enzymes in the liver you get far different results than if you gave low levels over long periods.