this post was submitted on 05 Dec 2023
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Vaccines can be delivered through the skin using ultrasound. This method doesn’t damage the skin and eliminates the need for painful needles. To create a needle-free vaccine, Darcy Dunn-Lawless at the University of Oxford and his colleagues mixed vaccine molecules with tiny, cup-shaped proteins. They then applied liquid mixture to the skin of mice and exposed it to ultrasound – like that used for sonograms – for about a minute and a half.

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[–] [email protected] 29 points 11 months ago (3 children)

I'm diabetic. This would be awesome!!

[–] [email protected] 9 points 11 months ago (2 children)

Miniatyrize ultrasound part, make it communicare with those glucose sensors that are placed on shoulder, make it portable enough and Presto! Artificial pancreas.

[–] [email protected] 5 points 11 months ago
[–] [email protected] 2 points 11 months ago

Even the long application time is no issue there, since you just carry the device with you

[–] AlecSadler 5 points 11 months ago (5 children)

I'm dumb...what does being diabetic have to do with inability to get needle vaccines? I'm seriously asking.

[–] [email protected] 13 points 11 months ago

There's type 1 and 2 diabetes. I believe type 2 requires you to regularly prick your fingers to test your blood sugar levels several times a day while type 1 requires mandatory insulin shots into your stomach a few times a day. Basically a diabetic fuckin hates needles for good reason and to be able to do that with ultrasound would be rad.

[–] [email protected] 5 points 11 months ago* (last edited 11 months ago) (1 children)

It could be that if vaccines can be attached to a "cup-like protein" and given through the skin, than maybe insulin could too. Just less needle sticks overall

[–] AlecSadler 2 points 11 months ago

OHHHHHHH. Jeez it took me way too long for this to click. Thanks!

[–] Lepsea 4 points 11 months ago

If i remember correctly diabetic people have a hard time closing a wound

[–] [email protected] 1 points 11 months ago* (last edited 11 months ago)

The pancreas is an organ which produces a hormone called insulin, which regulates the intake of sugar from the blood.

In type 1 diabetics, the pancreas has been damaged by an autoimmune reaction, so they need to monitor their blood sugar and administer insulin to the blood using external equipment.

This can be done manually with a needle and glucose tester for measuring blood sugar, and a syringe for administering insulin, or an insulin pump and continuous glucose monitor, which adhere to the skin and have continuous access to the blood through a cannula.

Being able to administer insulin without a needle or cannula would eliminate a common point of failure in this system. The cannula of an insulin pump can easily become dislodged from the skin when disturbed and leak insulin onto the surface, resulting in high blood sugar and wasted insulin.

[–] [email protected] 1 points 11 months ago (1 children)

Will anyone actually do this, if it takes 1-1.5 minutes and needs a heavy machine?

[–] [email protected] 1 points 11 months ago (1 children)

People who don't like needles? Or do you mean institutions?

[–] PsychedSy 1 points 11 months ago (1 children)

I'm sure there are some people that would help, but I went from blood draws making me nearly pass out to self injecting meth(otrexate) once a week after my RA diagnosis.

[–] abraxas 2 points 11 months ago (1 children)

A blood draw ruins my week (not exaggerated). If I were diagnosed with diabetes I would end up dead. For me, anything that avoids a needle is worth it.

[–] PsychedSy 1 points 11 months ago (1 children)

Exactly. For you it'd likely be worth it. For people like me it'd be a waste - the answer was to nut up. I also require hour-long transfusions every two months. I'm not sure they could do anything but maybe put you under anesthesia for something like that.

[–] abraxas 1 points 11 months ago (1 children)

Yeah, I really can't imagine. My wife (who works in the medical field) tried to help me "get used to" needles and I didn't make a single lick of progress. With my kind of issue, it's common that the issue gets worse and not better if you get shots more often. Something about my subconscious forming a feedback loop with my reactions to create worse reactions over time. I didn't stop breathing from shots when the symptoms started when I was 8 or 9, just got dizzy/lightheaded and passed out.

[–] PsychedSy 1 points 11 months ago (1 children)

That sounds insanely distressing. I won't recount my bad experiences. None of them were harmful, but some nurses aren't as gentle as others.

[–] abraxas 2 points 11 months ago (1 children)

Yeah. I half-mentioned it elsewhere. I was in an ER and needed to have blood drawn. I was just barely staying conscious by leaning back with an ice pack, but they needed the room so a nurse came in and said "yeah you're fine" and lugged me from the blood-draw chair into a wheelchair. My wife wanted to hit her (lol) but it took the 2 of them to keep me from hitting the floor instead of the wheelchair because I started to black out from suddenly standing.

Some nurses are idiots.

[–] PsychedSy 1 points 11 months ago (1 children)

Jesus. I had a nurse accidentally throw a vial (one of like 11. It was my first RA blood draw) in the biohazard bin. She took one look at me and ripped that box off the wall to carefully extract it, risking herself in the process.

Recently they moved half the infusion staff to another location and a nurse I'd never met, who's a super nice guy, just isn't as careful when he's finishing up as the women have been. First bruise I've gotten from them in like two years. My arm looked like I was shooting up heroin or something. No real damage, but it's unsettling.

[–] abraxas 2 points 11 months ago (1 children)

Yeah, exactly. And I agree that there's separate categories for skill, dedication, and niceness. Some folks are damn good but lazy and don't care, others make up for being "only ok" by trying really hard and caring a lot, and some are just friendly when they screw up. It's nice to have more than 1 of those 3 at a time. Someone in my family went to a weight loss doctor and asked me to come along. She was the friendliest doctor I'd ever seen... and the appointment finished with "I'm really lost. I don't think there's anything else we can try right now. You're doing everything right". Don't know WHAT that was in the spectrum of skill and dedication. Maybe it's true, maybe she was just giving up. But from what I've seen/heard, it's definitely better than "well try harder, eat less, and workout more" that heavier patients hear from doctors who don't even ask what they're eating or what their workout regimen looks like.

I don't have to deal with a lot of that stuff you do, but I can imagine it since what little I deal with has shown me multiple sides of people (doctors too, I suppose).

[–] PsychedSy 1 points 11 months ago

My worst was my GP/PCP saying all men are a little ADHD. I got an official diagnosis with ease. Now I use a doctor recommended by a friend and she's fantastic. All my docs are women now, and I only use men for mental health stuff. It's worth it hunting down the right people if you can. I'm kinda lucky with my insurance. I use a badass local pharmacy, too, and their competence is mind blowing compared to big corporate pharmacies.

What fucked me up with the nurse was that the first time I met him he just finished the infusion. Took the tape off and pretty much dropped the IV rig. It just bruised a bit, but was distressing to watch. The second time I saw him I was like "oh fuck oh shit" but he had no problems. Got it on the first attempt. Painless. He's just way too chill on the back end.