The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
It's easy: have nothing else going for you in life and making fun of others becomes a super fun way to pass time.
Basically playground bullies who never matured beyond that mentality.