The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
The argument being that if they aren't blocked at an instance-level, due to how the federation works, those comments could very easily spill over into these threads. Those that do want to participate in good faith would need to create an account with an instance that is federated.