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Single psilocybin trip delivers two years of depression relief for cancer patients
(www.sciencedaily.com)
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Ketamine too. You can get it in a clinical setting without a prescription. It has a half life of about twenty minutes so if it’s not your thing it’s over quickly. One session gets you two separate doses, so you trip for about an hour, and feel totally normal afterward. Great for depression too.
In a non clinical setting, ket lasts about two hours but you pull up more sober than weed or booze.