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World-first lung cancer vaccine trials launched across seven countries (www.theguardian.com)

submitted 3 months ago* (last edited 3 months ago) by [email protected] to c/[email protected]

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Doctors have begun trialling the world’s first mRNA lung cancer vaccine in patients, as experts hailed its “groundbreaking” potential to save thousands of lives.

Lung cancer is the world’s leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor.

Now experts are testing a new jab that instructs the body to hunt down and kill cancer cells – then prevents them ever coming back. Known as BNT116 and made by BioNTech, the vaccine is designed to treat non-small cell lung cancer (NSCLC), the most common form of the disease.

The phase 1 clinical trial, the first human study of BNT116, has launched across 34 research sites in seven countries: the UK, US, Germany, Hungary, Poland, Spain and Turkey.

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[–] [email protected] 4 points 3 months ago (1 children)

Someone who's more familiar with mRNA technology please explain to me.

I know that mRNA works for viruses because it trains the body on specific protein structures the virus uses to easily identify them, but in terms of cellular organisms like cancer and bacteria where the proteins are hidden behind the cell wall, especially in the case of cancer where it's not even clear where in the DNA the mutation will take place, how the heck does this work??

[–] [email protected] 7 points 3 months ago

The jab uses messenger RNA (mRNA), similar to Covid-19 vaccines, and works by presenting the immune system with tumour markers from NSCLC to prime the body to fight cancer cells expressing these markers.

Tumor markers have traditionally been proteins or other substances that are made at higher amounts by cancer cells than normal cells. These can be found in the blood, urine, stool, tumors, or other tissues or bodily fluids of some patients with cancer. Source: https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet

I am not a MD or anything but from what I can tell based on the tumor marker described above it sounds like it would work pretty much the same as the covid vaccine? Maybe the proteins build up like plaque and the mRNA just stops the protein production gene expression? Again I do not know a ton about cancer.