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this post was submitted on 18 May 2024
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Hardy-Weinberg isn't appropriate here. If all alleles were neutral, they'd get slowly lost or move toward fixation at a rate proportional to the mutation rate by genetic drift. In the absence of negative selection, new variants that are deleterious without modern medicine would do a random walk in allele frequency, meaning some would become prevalent. But the population is so large they would take far too long to be completely fixed.
Hardy-Weinberg is a model that makes by true assumptions (like zero mutation rate and infinite, isolated populations).
You seem to be lost in the weeds a bit. Of course hardy-weinberg is a model that never exists in reality. It's a good method to explain the importance of selection pressure on populations.
Without an active selection agent on the allele, it's frequency in the population remains the same.
Now in reality there is no such thing as zero selection pressure on any allele. Having a deleterious or advantageous allele 49.99cM away exerts selection pressure.
However allelic frequencies without a strong selection acting on them remain relatively stable.
You're not understanding. Without selection, real populations would have changing allele frequencies. They would not stay static. That's because random sampling exists, but only outside of the H-W model.
Random sampling has a significant effect when the population size is smaller. Say less than 10,000 individuals.
It has very little effect as the population size increases to say something a little more than 8,000,000,000 individuals.