For VtM its easy as take fist of caine and lightning strike.
Yeah you ripped someone's heart out in 3 seconds because your fast and strong, cool now you're covered in blood and a walking Masquerade breach becaise you punched through someone's ribcage The cops are on their way, second inquisition are listening in on radios, the Prince is disappointed that an elder is this careless and the sheriff is going to laugh at you as you're turning to dust because disciplines can only do so much before you fall into torpor because you're out of blood points/at max hunger.
To use another IRL example, humans did drive the wooly mammoth to complete extinction with little more than sharpened rocks attached to sticks.
Humanity's ability of cooperation is a massive force multiplier and let's us accomplish tasks that would kill and individual.