I used intel nuc j5005 for 4 years iirc with 2 bay hdd enclosure, Orico brand. Never had any problem that i hear about such as random diaconnecting. Granted i used it to host my media. So i dont pratically mind if the data is gone.
I used openmediavault with usb boot drive. Internal 2.5’ drive as docker appdata. All my media files is stored on the external enclosure. The only problem i noticed is the temperature but thats because of high ambient temp.
If youre planning to use ext enclosure for critical data. Might wanna think twice. But, if you have proper backup plan. Sure why not.