Futurama

Tie between:

If anyone needs me, I'll be in the angry dome

angry muttering as the PES flies away

and

Well Susie, it isn't foreigners, it's global warming

Gwabu wabu?

Uh, sure...

I was gonna go yachting in those feet!

Bender, depressed walks up to a bar:

"Gimmie your largest, strongest, cheapest drink"

If we hit that bullseye, the rest of the dominoes should fall like a house of cards. Checkmate!

Not exactly an iconic line, but I love the delivery:

"Have you heard of the Monks of Deshuba?"

Fry: "I've... not heard of them."

Futurama's great for nerdy science gags, social satire, and pop culture spoofs, but its best jokes are always uniquely stupid twists of language like this.

"I'm going to remind Fry of his humanity, the way only a woman can."

"You're going to do his laundry?"

Edit - the one that had me literally rolling off the couch because I was laughing so hard was, "That just raises further questions!"

What makes a man turn neutral?

The one I use most often: "I've heard worse excuses to drink".

There's not a restaurant built that I can't fly - Zap Brannigan

My lead pipe hurts.

I'll use the poor as a source of teeth for aquarium gravel

And Fry, you've got that brain thing!

• I already did!

“Take the deal, Fry! If there's a delicious cake, isn't it better to have one slice than none at all? Even if four other guys eat the other four slices, and they're all thrusting their sweaty naked bodies against the cake?”

"wooooooooo"

Gundersons Nuts! They're Nut so good!

I'm Shocked. SHOCKED! well not that shocked.

Hey. Fry. Pizza going out. C'MON!

"What about what?" - Philip J Fry responding to the professor yelling WHAT in a tiny ship in Fry's ear when the professor and crew controlled tiny robot versions of themselves to sneak inside Fry's body

I'm Scruffy, the janitor.

I sublibed with obly tribial blain dabblage.

MY LEG FEELS FUNNY

...

MY LEG FEELS BETTER

This isn't a productive area of discussion.

"Your mother!"

I can't believe everybody's just ad-libbing!

Robot house

I could do without these boobs flopping about

The butter in my pocket is melting!