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Bottled water contains 100 times more plastic nanoparticles than previously thought
(www.euronews.com)
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I think it's still a bit early for us to know how it's affecting us. It's the kind of data that takes a lifetime of micro plastics to see how it will kill us. But knowing how much cancer various plastics already give us, it's safe to assume this is a bad thing.
This isn't like smoking or drinking. There isn't any control group. We have no population to compare a lifetime of microplastic exposure against. It isn't like lead, either. Plastics pollution to date guarantees a continuous supply of microplastics for decades/centuries.
You're right, I assume that even at the very best, an uncontacted tribe would still be contaminated to some extent