Hardware

Sure, if you’re keeping everything outside the case you could conceivably get something working with a different motherboard. I have built laptop mbs into tvs, cabinets etc. for different projects. But it would require an in depth understanding of all the components involved and most likely some petty good soldering skills in order to match up/replace connectors etc. By the time you are done you would find you would have better off just buying the right mb replacement on eBay.