The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
Exactly. r/thedonald started as a tiny joke sub started by 4Chan that wasn't dealt with until it became a festering cesspool of hate that became big enough to be a serious problem, brigading other subs and spreading hateful rhetoric. It has to be nipped in the bud and made clear that it is not welcome.