Science Memes

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YOLO (mander.xyz)

submitted 6 days ago by [email protected] to c/[email protected]

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[–] [email protected] 17 points 6 days ago (9 children)

We used purified high fat diets, one at 40% and one at 60% and compared the two. We had a whole other project where each group were supplemented with lentils but we I focussed on just the difference between those two diets where the only variable between them were the carb/fat percentage, they were otherwise the same/pure.

[–] [email protected] 2 points 6 days ago (4 children)

So do you recommend a high fat diet?

[–] [email protected] 4 points 6 days ago (3 children)

60% produced a more dramatic phenotype and I remember it being the most popular diet in animal studies (I did all this 10 years ago so the details are a little fuzzy) so I'd probably go with that one.

[–] FeatherConstrictor 1 points 5 days ago (1 children)

Can you explain what you mean by a more dramatic phenotype?

[–] [email protected] 3 points 5 days ago (1 children)

In animal research we often refer to genotype and phenotype. Genotype refers to the set of genes the animals the animals carry (what they are capable of expressing) and phenotype refers to the physical/clinical expression/presentation/characteristics of the animal or disease state. My guys were all "wild type" meaning they're just "normal" standard mice and we induced the "obese phenotype" (obese disease state with the associated characteristics and physical presentation associated with the disease) with the two high fat diets. 60% had a greater impact on inducing these changes compared to the control group than the 40% group.

[–] FeatherConstrictor 1 points 4 days ago

Ah thanks for the response!

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