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Boosting brain’s waste removal system improves memory in old mice (medicine.washu.edu)

submitted 1 week ago by [email protected] to c/[email protected]

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[–] phdepressed 17 points 1 week ago

Actual article. https://www.cell.com/cell/fulltext/S0092-8674(25)00210-7

Essentially they find that interleukin-6 (IL-6) a well-known inflammatory signal is important to neuronal lymphatics which are key to brain waste removal. Frankly, not too surprising imo but they do drill it down very well to what cells are effectors/affected. They use a drug, PLX5622, to inhibit this IL-6 activity and see significant improvement to mice where neuronal inflammation had been induced, genetically or surgically.

I'm very sleepy so didn't read into any side-effects they notice or discuss as possibilities.