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Unpopular opinion, I know, but humans simply are not built for space. Trying to force this square peg into a round hole is such a tremendous waste of resources at this point.
I wish we could divert all of human space flight budget to automating probes. Weโd be mining the asteroid belt by now. Once we have space-based automated manufacturing, then it will be the time to bring in the humans.
It's a scary word to use, but humanity does need some form of eugenics for space travel.
No, not the racial kind.
We need to breed resistance to radiation and adaption to low oxygen or low gravity environments.
We need to be able to be stuck in cramped quarters around other people for years without eventually killing each other.
We need to be able to be cryogenically frozen for long periods of time and then reanimated.
None of this is possible without fundamentally editing the genes of humans. We essentially need to evolve into a new species.
Or we could just like shield radiation, and provide oxygen/gravity.
Relying on evolution for this sounds like it'd take a couple millennium longer than just like a spinning slab of concrete with a rebreather inside.