this post was submitted on 05 Aug 2024
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TechTakes

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Big brain tech dude got yet another clueless take over at HackerNews etc? Here's the place to vent. Orange site, VC foolishness, all welcome.

This is not debate club. Unless it’s amusing debate.

For actually-good tech, you want our NotAwfulTech community

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Need to let loose a primal scream without collecting footnotes first? Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid: Welcome to the Stubsack, your first port of call for learning fresh Awful you’ll near-instantly regret.

Any awful.systems sub may be subsneered in this subthread, techtakes or no.

If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post — there’s no quota for posting and the bar really isn’t that high.

The post Xitter web has spawned soo many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)

Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.

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[–] [email protected] 15 points 3 months ago (2 children)

Regarding the paper "Discovery of a structural class of antibiotics with explainable deep learning", a comment by e. e. arroyo:

"Yes! we can make explainable predictions of compounds with AI now!"

  • They could only explain 15% of predictions
  • They could only understand 9% of those explanations
  • 60% of those were wrong
  • The 4 active compounds left are probably, arguably, not even a novel class
[–] [email protected] 11 points 3 months ago (1 children)

i'm not reading all that, at least now, but i'd just notice that carboxylic acids are notoriously terrible at crossing membranes unless some trickery is used, so there could be massive issues downstream. issues that, you know, can be effortlessly pruned at early stage of drug development

[–] [email protected] 10 points 3 months ago

I do remember part of the appeal for SETI@home back in the day was the ability to analyze the data that heuristics had ruled out but not conclusively, so it's not like there's no precedent. Of course the other benefit of BOINC was using the "spare" cycles in consumer hardware rather than purpose-building more massive power and water-hungry datacenters, so the cost was arguably negligible even if the benefits were similarly small.

[–] [email protected] 6 points 3 months ago

"for SBV values of explaining"