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Twice, both related to my Crohn's Disease.
The first was in preparation for my first colonoscopy, where I was told that I was only allowed clear broth, clear soda, coffee, and water for 24hr before taking the colon prep solution. I didn't think the diet would give a mile-long headstart before the prep solution, so I enjoyed copius amounts of clear broth and coffee, which ran through me like a river, resulting in the mishap. The bathroom was only 10ft away from me, but it was still too far given the rapid pressure buildup.
The second was during an insurance conflict about my Crohn's Medication, resulting in a flareup and multiple weeks of gut agony and loose stool. It got to the point where no flatulence was trustworthy, and I took a gamble because I was so tired of getting up to run to the restroom every time I felt something bubbling (10+ restroom visits a day, each at the slightest sign of stomach rumbling will do that to a motherfucker).
It is always humiliating, even when I am home alone, and I am hyper concious about the possibility, even when in remission. It fucking bites.