I think remember a post on hacker news (not that I could find it again), about a dev who was losing his sight and managed to configure emacs for his needs because it's the most flexible editor.
Quick googling turns up emacspeak and speechd-el
zupatol
joined 10 months ago
That was my first thought, but isn't this text-to-speech? That would be emacs without screen, not emacs without keyboard.