I had no issues with compatibility, just made sure to save documents to older microsoft office formats in the hopes of avoiding issues.
I never had to use an exam browser or anything like that, I'd imagine you'd want to have a polite conversation with the instructor if that were to occur, perhaps they can make an exception or allow you to do it on a library computer
Collaboration was always over google docs, so there were never any problems working with others. My CS classes were all expected to be done in Linux VMs so that was sort of ideal. Other science/humanities classes were totally software-agnostic.
I've given up on GOG. No linux client means the whole process of installing/launching games is rather tedious. Also linux game dependencies can be annoying to resolve
Steam on the other hand just handles everything. If it doesn't work at first, it probably will with proton.
I'd love to support an anti-DRM store, but it's tough when there is so much friction when actually playing the games