For what it's worth, I use power profile daemon (PPD) on my AMD Framework 13, but also setup the systemd service for powertop's auto-tune, which is less invasive than TLP and can coexist with PPD (usually).
I've been running this way for a few days with no unexpected behavior, and the difference between PPD powersave and PPD powersave + powertop --auto-tune seems to be about ~1W at idle (i.e. I see a ~4.5 watt idle instead of a ~5.4 watt idle).
I'm not running Debian, but powertop is in Debian's repos so it may be worth a try. Powertop can also be used as a purely diagnostic tool to show you the estimated power draw in real time (after calibration), so you can see immediately if tweaks make a difference.