You can get a daily SBB/CFF train ticket for cheap by asking your city. Moreover there is a minimal distance you must commute by train every day to make the General subscription (GA or AG) a better deal than buying a half card ticket.
Shops close early in most places and we do not have 24/7 options.
Each canton has its own autonomy which means for instance the education system and other cantonal laws can differ from one canton to another.
You pay different tax % for the same income depending on the canton and the city in which you live.
You can go from a region speaking one language to a another quite quickly. This is why English is most of the time very useful since we have 4 official languages. Rostigraben is the name we give to this concept.
Admin.ch has a lot of information about most of the questions one can have on administrative matters.
Wallis is objectively the best canton. (This a joke don't kill me π)