There’s a crapload of interesting things in this paper!
I suffer from axial spondyloarthritis which causes severe fatigue chalked up to trouble sleeping and ongoing inflammation usually. Underlying symptoms are treated with biologic TNF and IL-17 inhibitors which coincidentally are the same pathways mentioned here for ME. There’s also a new treatment targeting T-Cells selectively approved in Russia and currently tested in China although it has only a biologic-level effectiveness despite the hype according to local reports. It seems to not work for those without HLA-B27 antigen which appears to similarily divide those suffering from AS into two groups like described here with ME.
It sounds like guys with ME have a chance at an effective treatment fairly soon. Cautious yay?