this post was submitted on 02 Nov 2023
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Would you group MDMA in this classification? I don't think MDMA is an SSRI.
"Psychedelic" is also a much more wide ranging classification. MDMA isn't really a psychedelic.
SSRI's directly affect the body's absorption of serotonin, meaning serotonin lingers around more. My hypothesis is that MDMA affects the release of serotonin, specifically it sustains the natural release for longer.
MDMA is classified as an amphetamine. It has some characteristics of a psychedelic as it is similar, structurally, to mescaline. You get the speedy effects as well as trippy effects, basically. It has a more distributed effect on dopamine and serotonin receptors but the concept is basically the same as far as how neurons "interpret" drugs.
In the case of MDMA, it does increase serotonin, dopamine and noradrenaline levels. So, by using your gland analogy with MDMA makes more sense in that these chemicals will be depleted and can leave you feeling like garbage the next day. Combine that with how neurons "see" different drugs, and that is more of a complete picture. You can only force feed your brain so many neurotransmitters before it needs to recover.
Serotonin syndrome is also a risk with MDMA. Not only are your neurons making more serotonin, it may not have a place to go.
Yes, MDMA is an amphetamine, as per the name. However it is significantly different to mescaline, which has an extra functional group off the carbon ring. In 2D the molecules look very similar, but in 3D they're very, very different, and as such their function differs also. Mescaline is hallucinogenic, MDMA is not particularly so.
I'd be hesitant to attribute speedy effects to MDMA, in particular with tablet form, in which various drugs tend to be mixed. MDMA in pure form has nowhere near the same stimulant effect as speed, or ecstacy pills laced with speed or whatever else.
I don't think MDMA alone is likely to cause serotonin syndrome, however mixing it with SSRI's most definitely would be a high risk. Rather, the common issue with MDMA, particularly with excessive use over time, is serotonin depletion.
Chemical discussions aside, MDMA cut with other drugs is nasty. The hangovers from mixed MDMA are horrid, to say the least. More days of my youth than I would like to admit were spent in bed because of that trash.
Risk is risk. I hope that someone reads our discussion to be more familiar with those risks, TBH. Drugs are drugs, and drugs affect people in different ways.
But sorry if I got distracted with psychedelics rather than MDMA. I haven't read into MDMA in a while. I have been so entrenched in the mushroom world for a bit that everything reads like a conversation about psychedelics. (That spawned a yet another hobby of growing gourmet and medicinal mushrooms, but I digress.)
I've done MDMA many times, and unless I got it contaminated the same way every time, it definitely has a strong stimulant effect.
I should probably note that I did a reagent test on many of the batches I got, so I'm fairly confident it was the real thing.
It has some stimulant effects, yes, but it's not as strong as speed and relatively weak compared to other amphetamines.
Not as long lasting. "Not as strong" really depends on the dose. I take Adderall now and it's a lot milder than when I did MDMA.