Hardware

Not a Apple use case per se, but if you play economic strategy games (transport simulation, city builders, complex town builders) with heavy modding, even modern CPUs can start to buckle in the late game on large maps; this is mostly due to ST performance.

One (albeit niche) example is Cities in Motion 1 (2011). They have a custom engine that is single threaded. If you mod in the largest map size, free look and start building out a large network, you will see low FPS when running 1440 resolutions even on modern CPUs.