Transfem

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A community for transfeminine people and experiences.

This is a supportive community for all transfeminine or questioning people. Anyone is welcome to participate in this community but disrupting the safety of this space for trans feminine people is unacceptable and will result in moderator action.

Debate surrounding transgender rights or acceptance will result in an immediate ban.

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This community is supportive of DIY HRT. Unsolicited medical advice or caution being given to people on DIY will result in moderator action.

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To make such a request, at the start of the body of your post, not in the title, the first line should look like the this: [Requesting Engagement from _________]

Some helpful links:

The Gender Dysphoria Bible // In depth explanation of the different types of gender dysphoria.
Trans Voice Help // A community here on blahaj.zone for voice training.
LGBTQ+ Healthcare Directory // A directory of LGBTQ+ accepting Healthcare providers.
Trans Resistance Network // A US-based mutual aid organization to help trans people facing state violence and legal discrimination.
TLDEF's Trans Health Project // Advice about insurance claims for gender affirming healthcare and procedures.
TransLifeLine's ID change Library // A comprehensive guide to changing your name on any US legal document.
Gender Spectrum // Resources for youth, parents and family, educators, mental health professionals and faith leaders.

Support Hotlines:

The Trevor Project // Web chat, phone call, and text message LGBTQ+ support hotline.
TransLifeLine // A US/Canada LGBTQ+ phone support hotline service. The US line has Spanish support.
LGBT Youthline.ca // A Canadian LGBT hotline support service with phone call and web chat support. (4pm - 9:30pm EST)
988lifeline // A US only Crisis hotline with phone call, text and web chat support. Dedicated staff for LGBTQIA+ youth 24/7 on phone service, 3pm to 2am EST for text and web chat.

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Sublingual Estradiol Offers No Apparent Advantage Over Combined Oral Estradiol and Cyproterone Acetate (pubmed.ncbi.nlm.nih.gov)

submitted 18 hours ago* (last edited 18 hours ago) by [email protected] to c/[email protected]

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Abstract

Purpose: Chronic gender-affirming hormone therapy (GAHT) with sublingual estradiol (SLE) has not been studied. We aimed to compare GAHT with SLE only, to combined oral (CO) estradiol and cyproterone acetate, in treatment-naive trans women.

Methods: Twenty-two trans women enrolled into either the CO arm or the SLE-only arm (0.5 mg four times daily) in this 6-month prospective study. Anthropometric and laboratory variables were collected at baseline and 3 and 6 months. At the study beginning and end, body composition was measured by dual-energy X-ray absorptiometry and bioelectrical impedance, and gender dysphoria, sexual desire, and function were assessed by validated questionnaires.

Results: Subjects in the SLE were older, 26.3±5.8 years versus 20.1±2.3 years, p=0.006. All anthropometric, body composition, and laboratory variables were identical at baseline. Although dysphoria appeared greater, and sexual function lower at baseline in the CO group, this canceled out after age adjustment. Both treatments induced similar biochemical and hormonal changes. Creatinine, hemoglobin and cholesterol decreased significantly, while testosterone was suppressed to the same level in both groups: 3.22 [1.47-5.0] nmol/L in the SLE group and 2.41 [0.55-8.5] nmol/L in the CO, p=0.65. Significant changes in body composition toward a more feminine body were noted in both groups. Dysphoria did not significantly improve in either group, while sexual desire and function decreased at six months in both, p<0.001.

Conclusions: Both treatments achieved similar clinical changes. At this stage, SLE, which repeatedly induces alarming excursions of serum estradiol throughout the day, appears to offer no advantage over the CO approach.

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[–] [email protected] 1 points 3 hours ago (1 children)

Personally, my desire pretty much disappeared... sometimes it super bothers me, especially since I know things need to stay engaged down there if I ever opt for certain surgeries. It's not bothersome enough that I've seriously brought it up with my doctor, but I did ask to be prescribed progesterone to help as I've seen many anecdotes about it increasing sex drive and desire....zero change so far. I'd say it's pretty nice for the most part as there's this edge which is no longer there, buuuut I do sometimes miss actually feeling that type of desire. I have read that it just randomly returns eventually, so just doing my best to enjoy whatever this is for now 🤭

[–] [email protected] 1 points 2 hours ago

Progesterone can make desire or horniness return. However, in our experience and this might just be us it can bring with it a certain amount of dysmorphia.