Conservative
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Profit margins for pharmaceutical companies are typically between 10 and 20 percent in the US, 2020 & 2021 are exceptions as the covid shot boosted numbers considerably. Those are normal profit margins for industry.
And...
Their profits are not grotesque
20% of $1.2 trillion is $240 billion dollars. That is a grotesque amount of profit to make by holding people's health hostage.
What would you consider a reasonable profit?