Probably doesn't count as 'lesser known' but my answer is Galaxy Quest
Science Fiction
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For me it would be The Expanse.
Loved the Audiobooks, TV show, and comics. A lot of the science behind the way ships move, microgravity, spin gravity, and gravity wells was all well researched.
Farscape has been covered, so to bring up something that definitely hasn't been mentioned, Charlie Jade. A Canadian/South African co-production from the 2000s about three parallel Earth versions of Cape Town colliding. Awesome show, but I don't think I've ever met anyone who knows it.
I was mad obsessed with Dollhouse and Fringe. It felt like both ended way too soon, but at the same time they didn't outstay their welcome as so many shows do.
Firefly will never not be my favorite. Truly before its time... imagine how many seasons it would have run for if it were made today and on a different network...
It would be Netflix's Lost in Space for me. Love that show. It's got such a well-written plot and great characters, I'm so sad that not many people have seen it. It's only three seasons too.
Without a doubt, Doctor Who.
They Live: John Carpenter's documentary about what yuppies and Republicans have been doing to America since 1980.